ADME/PK Profiling Services

Comprehensive ADME/PK Services

In Vitro ADME Screening

• Metabolic stability (microsomes/hepatocytes across species)
• CYP450 inhibition/induction, transporter assays (P-gp, BCRP)
• Plasma protein binding, solubility, and permeability (Caco-2/PAMPA)
• Reactive metabolite identification (glutathione trapping, covalent binding assays)

In Vivo Pharmacokinetics (PK)

• Rodent and non-rodent PK/PD studies (IV, PO, SC routes)
• Tissue distribution, mass balance, and excretion (bile, urine, feces)
• Bioavailability (F%), half-life (t1/2), clearance (CL), and volume of distribution (Vd) profiling

Specialized Assays

• Blood-brain barrier (BBB) penetration studies
• Drug-drug interaction (DDI) risk assessment
• PBPK/PD modeling for human dose prediction

Applications Across Therapeutic Areas

•     Small molecules & oral biologics
•     Oncology, CNS, and immunology candidates
•     Gene therapies & oligonucleotides