ADME/PK Profiling Services

Accelerating Drug Development with Precision ADME/PK Solutions

At HuaTeng Biotechnology, we deliver end-to-end ADME/PK profiling services to optimize drug discovery and development, ensuring robust pharmacokinetic and safety data for small molecules, biologics, and novel modalities. Our globally compliant studies bridge preclinical and clinical phases, empowering you to prioritize candidates, mitigate attrition risks, and meet regulatory milestones.

Comprehensive ADME/PK Services

In Vitro ADME Screening

Metabolic stability (microsomes/hepatocytes across species)
CYP450 inhibition/induction, transporter assays (P-gp, BCRP)
Plasma protein binding, solubility, and permeability (Caco-2/PAMPA)
Reactive metabolite identification (glutathione trapping, covalent binding assays)

In Vivo Pharmacokinetics (PK)

Rodent and non-rodent PK/PD studies (IV, PO, SC routes)
Tissue distribution, mass balance, and excretion (bile, urine, feces)
Bioavailability (F%), half-life (t1/2), clearance (CL), and volume of distribution (Vd) profiling

Specialized Assays

Blood-brain barrier (BBB) penetration studies
Drug-drug interaction (DDI) risk assessment
PBPK/PD modeling for human dose prediction

Applications Across Therapeutic Areas

Small molecules & oral biologics
Oncology, CNS, and immunology candidates
Gene therapies & oligonucleotides

Why Choose HuaTeng Biotechnology for GLP-Compliant Testing?

Trusted Quality. Global Compliance. Proven Execution.

Global Compliance: AAALAC-accredited facilities with IACUC oversight, aligned with EU Directive 2010/63/EU and USDA standards—ensuring full regulatory acceptance across major markets.

Advanced Imaging Capabilities: Integrated platforms including DSA, IVUS, angiography and micro-CT, enabling real-time evaluation of device performance and in vivo outcomes.

Custom Model Development: Species-specific animal models tailored to complex disease conditions, improving translational relevance and clinical predictability.

Integrated Histopathology Suite: SEM and TEM analysis supported by GLP-grade reporting, enabling seamless submission to PMDA, CE Mark and global regulatory authorities.

Custom Hotline

+86 15217198166

ht@htscience.com

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ADME/PK Profiling Services