Acute Lung Injury (ALI) Animal Model - LPS/Chemical-Induced
Acute Lung Injury (ALI) Animal Model - LPS/Chemical-Induced
Model Name
LPS-induced ALI model
Animal Strains
C57BL/6
Model Description
Huateng Biology’s Acute Lung Injury (ALI) Animal Models utilize gold-standard induction methods (LPS instillation, HCl inhalation, etc.) to accurately replicate human ARDS pathology. Ideal for anti-inflammatory drug screening, lung protection mechanism studies, and respiratory device evaluation. Models feature high reproducibility with multi-parameter validation including histopathology, cytokine profiling, and blood gas analysis.
Key Specifications
| Parameter | Description |
|---|---|
| Animal Strains | C57BL/6 mice, SD rats (custom strains available) |
| Induction Methods | Intratracheal LPS / HCl aerosol inhalation / Ventilator-induced injury |
| Modeling Timeframe | 24-72 hours (rapid establishment) |
| Validation Metrics | ① Lung W/D ratio ② BALF protein concentration ③ Inflammatory cytokines (TNF-α, IL-6, IL-1β) ④ Histopathological scoring (H&E) |
| Optional Analyses | Micro-CT lung density, arterial blood gas, pulmonary function tests, IHC (MPO/TLR4) |
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