Alzheimer's Disease (AD) Rat Model
Alzheimer's Disease (AD) Rat Model
Huateng Bio offers dual-pathway AD rat models: Transgenic (genetic) and Aβ-induced non-transgenic. Validated by Morris Water Maze cognitive deficits, Aβ plaque quantification, and synaptic marker analysis. Ideal for neurodegeneration drug screening and mechanism studies.
Model Description
Alzheimer's Disease is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and behavioral abnormalities. Our AD animal models replicate two critical pathological hallmarks:
1. Amyloid-beta (Aβ) plaque deposition
2. Cognitive-memory dysfunction validated by behavioral tests
Available in two categories:
• Transgenic AD models (genetic modification)
• Non-transgenic AD models (Aβ-induced pathology)
Applications
• Drug efficacy evaluation for AD therapeutics
• Neurodegeneration mechanism studies
• Behavioral cognitive assessment
• Biomarker validation
Modeling Methods
1. Anesthetize SD rats and perform stereotaxic surgery using a digital brain atlas.
2. Bilateral hippocampal microinjection: 5 μL Aβ25-35 per hemisphere (coordinates: 3.5 mm posterior to bregma, ±2 mm lateral).
3. Post-injection stabilization: 5-minute needle retention to ensure proper diffusion.
Validation & Testing
• Morris Water Maze Test (spatial learning/memory assessment)
• Histopathological Analysis (Aβ plaque quantification via Congo red/Thioflavin-S staining)
• Synaptic protein markers (Western blot/immunohistochemistry)
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