Arrhythmia Model

Applications

• Evaluation of anti-arrhythmic drug efficacy.

• Safety pharmacology (pro-arrhythmic risk assessment).

• Validation of Implantable Cardioverter Defibrillators (ICD) and pacemakers.

• Research on Sudden Cardiac Death (SCD) and post-infarction electrical instability.

Modeling Methods

HuaTeng Biotechnology employs precision induction techniques:

• Ischemia-Induced: Coronary artery occlusion/reperfusion to trigger malignant ventricular arrhythmias.

• Programmed Electrical Stimulation (PES): Using burst pacing and S1-S2/S1-S3 protocols to induce re-entrant arrhythmias.

• Pharmacological Challenge: Induction via Aconitine, BaCl2, or Isoproterenol for rapid screening.

• Surgical AV Block: Catheter-based or surgical ablation of the Bundle of His for bradycardia models.

Testing Items

• Surface & Intracardiac ECG: Real-time monitoring of QRS morphology, QTc interval, and rhythm disturbances.

• Electrophysiological Study (EPS): Measurement of Ventricular Effective Refractory Period (VERP) and conduction velocity.

• Arrhythmia Inducibility: Quantitative assessment of VT/VF thresholds via PES.

• Optical Mapping/Multi-electrode Array: (Optional) Spatial visualization of cardiac excitation waves.

Translational Insights for Researchers:

 In our Minipig Arrhythmia Models, the large cardiac mass allows for detailed mapping of re-entrant circuits, which is technically challenging in rodent models. This makes our platform ideal for testing medical devices like leadless pacemakers and ablation catheters.