Deep Vein Thrombosis (DVT) Model

Model Description

Deep vein thrombosis (DVT) is a critical precursor to pulmonary thromboembolism (PTE), with 70% of PTE cases originating from lower limb DVT. Our IVC thrombosis model in rabbits replicates human DVT pathology, enabling:

• High clinical relevance: Anatomical similarity in venous structure and hemodynamics
• Rapid thrombus formation: 24-hour modeling window for acute studies
• Controlled thrombogenesis: Spiral copper wire-induced endothelial injury and stasis

Key Advantages:
✓ High reproducibility: 95% thrombus formation rate
✓ Ethical compliance: Minimized surgical trauma via midline laparotomy
✓ Drug testing optimization: Validated with anticoagulants (e.g., heparin, rivaroxaban)

Applications

• Anticoagulant/antiplatelet drug efficacy evaluation
• Thrombectomy device performance testing
• Thrombosis imaging tracer development (MRI/CT contrast agents)
• Molecular mechanism studies (tissue factor, PAI-1 pathways)

Modeling Protocol —— Spiral Copper Wire-Induced IVC Thrombosis

1. Surgical Procedure:

• Midline laparotomy under ketamine/xylazine anesthesia (35/5 mg/kg)
• IVC exposure: Isolate infrarenal IVC segment
• Copper wire insertion: Place custom spiral copper wire (0.5mm diameter) into IVC lumen
• Close abdomen with layered sutures

2. Thrombosis Induction:

• Mechanism: Endothelial damage + foreign body reaction
• Thrombus maturation: 24-hour observation period

Validation & Testing

Technical Advantages