Model Of Pulmonary Artery Hypertension (PAH) Complicated With Lung Ischemia-Reperfusion Injury(LIRI)

Model Description

Pulmonary arterial hypertension (PAH) is a progressive disease caused by multiple factors, often secondary to circulatory and respiratory system disorders. Many patients undergoing thoracic cardiovascular surgery are diagnosed with PAH.

Meanwhile, lung ischemia-reperfusion injury (LIRI) is a common pathophysiological process after thoracic surgery, frequently observed in lung transplantation, sleeve lobectomy, and post-cardiopulmonary bypass scenarios. It is an unavoidable and severe complication that significantly impacts patient prognosis.

Applications

• Clinical treatment of PAH combined with LIRI
• Mechanistic studies of PAH combined with LIRI

Modeling Methods

• PAH combined with LIRI modeling method: A single intraperitoneal injection of monocrotaline in SD rats, followed by pulmonary artery clipping surgery 4 weeks later.
• Modeling cycle: 1-2 months.

Testing items

• Hemodynamic measurements and right ventricular hypertrophy index
• Gross observation and histopathological analysis of lung tissue