Ovariectomy Induced Osteoporosis Model

Model Description

Osteoporosis refers to a condition where the bone quantity is lower than normal, with altered bone structure, leading to corresponding bone diseases. It is a metabolic bone disease caused by multiple factors, characterized by an imbalance in the ratio of calcium salts to matrix and a reduction in bone mass per unit volume.

Osteoporosis is classified into primary and secondary types. Primary osteoporosis is associated with aging and postmenopausal estrogen deficiency in women. Secondary osteoporosis is often due to factors such as nutrition, medications, or systemic diseases.

Applications

• Development of postmenopausal osteoporosis-related drugs
•  Research on the mechanisms of postmenopausal osteoporosis
•  Evaluation of the efficacy and safety of bone cement and other medical devices

Modeling Methods

• First, make a midline incision into the rabbit's abdominal cavity.
• In the surgical group, both ovaries are removed, and the abdomen is closed.
• In the sham group, the abdomen is opened to locate the ovaries, which are then left intact before closing the abdomen. 
• Modeling cycle: 3-6 months.

Testing items

• Whole-body bone mineral density (BMD) measurement
• Bone metabolism marker detection
• Biomechanical testing
• Histopathological analysis of bone tissue