Steroid-Induced Osteonecrosis Of The Femoral Head Model

Model Description

Steroid-induced osteonecrosis of the femoral head (SONFH) is a bone and joint disease in patients caused by long-term or high-dose corticosteroid use due to immune or rheumatic diseases. The condition is challenging to treat and often leads to disability.

SONFH progresses insidiously, and without timely intervention, it can result in femoral head collapse. This ultimately leads to severe functional limitations in the hip joint structure, making artificial hip replacement an unavoidable option.

Applications

• The study of bone diseases related to steroid use

Modeling Methods

• Inject 20 mg/kg/d of methylprednisolone sodium succinate into the bilateral gluteal muscles of SD rats alternately, repeated for 3 weeks.
• The cycle lasts for 1 month.

Testing items

• Micro-CT scan
•  Pathological examination of femoral tissue