Androgenetic Alopecia (AGA) Model
Androgenetic Alopecia (AGA) Model
The model mimics the pathological state of androgen-induced hair loss by injecting dihydrotestosterone (DHT) in mice.
Model Name
Androgenetic Alopecia (AGA) Model
Animal Strains
C57BL/6 Mice
Animal Gender
Male
Animal Age
6-8 weeks
Animal Weight
20-24g
Model Description
Androgenetic alopecia, also known as male/pattern hair loss, is influenced by genetic factors and androgen hormones. It primarily affects males but can also occur in females, albeit with less severity. This model mimics the pathological state of androgen-induced hair loss by injecting dihydrotestosterone (DHT) in mice.
Modeling Methods
- Adaptation: Acclimate mice for 7 days.
- Depilation: Remove hair from a 5×3 cm area on the dorsal skin (Day 0).
Treatment:
- Model Group: Subcutaneous injection of testosterone propionate daily for 28 days.
- Control Group: Subcutaneous injection of solution daily for 28 days.
- Minoxidil Group: Topical application of 2% minoxidil 30 minutes after modeling daily.
Testing items
- Skin Appearance Observation: Photograph the depilated area every 7 days and score based on the skin color chart.
The Chart of Skin Color
The Score Based on the Skin Color
- Hair Coverage Rate (%)
The Result of Hair Coverage Rate (%)
- Histological Analysis
HE Staining(20×)
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