Chronic Renal Failure (CRF) Model Induced By Cationic Bovine Serum Albumin
Chronic Renal Failure (CRF) Model Induced By Cationic Bovine Serum Albumin
The pathological model is highly specific and resembles human glomerulonephritis in its immunopathological mechanisms.As a result, it is an ideal model for studying chronic renal failure secondary to membranous nephropathy.
Model Description
The model is created using cationized bovine serum albumin (C-BSA) to simulate chronic renal failure.
Normally, the glomerular basement membrane carries negative charges.C-BSA, as a positively charged exogenous antigen, binds to the glomeruli.This binding triggers an immune response, forming immune complexes in situ.And then immune complexes lead to glomerulonephritis.
This pathological model is highly specific and resembles human glomerulonephritis in its immunopathological mechanisms.As a result, it is an ideal model for studying chronic renal failure secondary to membranous nephropathy.
Applications
Commonly used for studying the mechanisms and treatments of chronic renal failure secondary to membranous nephropathy.
Modeling Methods
- Injections of positively charged BSA (C-BSA) are administered to rabbits in the marginal ear vein
- Modeling cycle: 11 weeks
Testing items
- Renal function parameters
- Renal tissue pathological analysis
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