Femoral Vein Thrombosis Model
Femoral Vein Thrombosis Model
HuaTeng Biotechnology offers standardized Femoral Vein Thrombosis (FVT) models. Expertise in FeCl3-induced and stasis-induced thrombosis in swine and rats for anticoagulant R&D.
Applications
• Efficacy evaluation of systemic anticoagulants and targeted thrombolytics.
• Validation of peripheral venous stents and thrombectomy devices.
• Research on the molecular mechanisms of venous endothelial dysfunction and inflammation.
• Assessment of drug-eluting coatings on vascular grafts.
Modeling Methods
HuaTeng Biotechnology offers multiple induction techniques for FVT:
• Ferric Chloride ($FeCl_{3}$) Induction: Chemical-induced oxidative injury to the venous endothelium, resulting in a stable, fibrin-rich thrombus.
• Stasis-Induced (Ligation): Partial or complete ligation of the femoral vein to simulate clinical venous stasis.
• Combined Injury: Mechanical balloon injury combined with stasis for complex device-related thrombosis research.
Testing Items
• Hemodynamics: Color Doppler Ultrasound to monitor blood flow velocity and degree of occlusion.
• Thrombus Analytics: Longitudinal measurement of thrombus wet/dry weight, length, and volume.
• Coagulation Panel: D-dimer, Fibrinogen (FIB), PT, and APTT.
• Histopathology: Martius Scarlet Blue (MSB) staining for fibrin quantification; H&E for clot organization and vessel wall infiltration.
Related Animal Models
Explore other gene-edited animal models that complement our porcine research platforms
