Atrial Fibrillation Model
Atrial Fibrillation Model
Partner with HuaTeng Biotechnology for high-fidelity Atrial Fibrillation (AF) models. Expertise in rapid atrial pacing (RAP) and drug-induced methods in swine and rats for drug discovery and medical device testing.
Applications
• Screening of Class I-IV anti-arrhythmic agents.
• Validation of ablation catheters, mapping systems, and pulse field ablation (PFA) devices.
• Studies on atrial-specific ion channel remodeling and fibrosis.
Modeling Methods
• Rapid Atrial Pacing (RAP): Chronic high-frequency pacing via implanted generators (Ideal for structural remodeling).
• ACh-Induced AF: Pharmacological induction combined with burst pacing for acute screening.
• Catheter-Based Burst Pacing: Minimally invasive induction of paroxysmal AF.
Testing Items
• Electrophysiology (EPS): Measurement of Atrial Effective Refractory Period (AERP), conduction velocity, and AF inducibility/duration.
• ECG Monitoring: Detection of f-waves and R-R interval irregularity.
• Atrial Histology: Quantification of interstitial fibrosis and Cx43 expression.
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