Vascular Injury Model

Applications

• Efficacy testing of anti-restenosis drugs and drug-eluting coatings.

• Validation of endovascular devices (stents, balloons, scaffolds).

• Research on the molecular mechanisms of vascular smooth muscle cell phenotypic switching.

• Studies on vascular healing and re-endothelialization kinetics.

Modeling Methods

HuaTeng Biotechnology excels in diverse mechanical injury techniques:

• Balloon Injury: Catheter-based denudation of the carotid or coronary artery (Gold standard for swine).

• Wire-Induced Injury: Targeted endothelial damage in rodent carotid or femoral arteries.

• Perivascular Cuff Model: Induction of inflammatory remodeling via non-constrictive cuff placement.

• Carotid Artery Ligation: Flow-mediated vascular remodeling research.

Testing Items

• In Vivo Imaging: Intravascular Ultrasound (IVUS) or Optical Coherence Tomography (OCT) for real-time lumen measurements.

• Morphometry: Quantitative analysis of Intima/Media (I/M) ratio and stenosis percentage.

• Specialized Histology: Elastic Van Gieson (EVG) staining for elastic lamina integrity; H&E and Masson’s for architecture.

• IHC/IF: PCNA/Ki-67 for cell proliferation; α-SMA for SMC phenotyping; CD31 for re-endothelialization.

Whether you are studying acute thrombosis following injury or chronic luminal narrowing, our protocols are adjustable. We offer various injury "depths"—from simple endothelial denudation to deep medial stretching—tailored to your drug's specific mechanism of action.