Masugi Nephritis Model
Masugi Nephritis Model
The Masugi nephritis model in rabbits, also known as anti-kidney antibody nephritis, is a type of nephritis where heterologous antibodies directly bind to antigens in the glomerular basement membrane (GBM), leading to inflammation. It is a classic model for studying anti-GBM glomerulonephritis.
Model Name
Masugi Nephritis Model
Animal Strains
New Zealand Rabbits
Model Description
The Masugi nephritis model in rabbits, also known as anti-kidney antibody nephritis, is a type of nephritis where heterologous antibodies directly bind to antigens in the glomerular basement membrane (GBM), leading to inflammation. It is a classic model for studying anti-GBM glomerulonephritis.
Applications
- Development and basic research of glomerulonephritis-related drugs
- Development and basic research of anti-kidney antibody nephritis-related drugs
Modeling Methods
- Injection of sheep anti-rabbit kidney serum into the marginal ear vein of rabbits
- Modeling period: 3 months
Testing items
- Biochemical tests
- Renal histopathology examination.
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